Nucleic Acids Research高级编辑&德州大学西南医学中心David Corey教授重磅加盟2019CNAF!
嘉宾介绍
主要研究项目
- Identifying nuclear small RNAs and long RNAs that associate with Argonaute.
- Biochemical characterization of Argonaute and RNAi factor activity in the nucleus.
- Discovery of novel nuclear Argonaute interacting factors.
- Investigating the molecular mechanism of activating and repressing agRNAs.
- Searching for naturally occurring agRNAs.
- Studying the effect of chemical modifications on agRNA activity.
- Allele-selective inhibition with antisense oligos, siRNAs and single-strand siRNAs.
- Mechanism of allele-selective inhibition.
- Targeting other repeat expansion disorders.
- Mechanism of promoter-targeted LNAs, PNAs and other chemically modified nucleic acids.
- Optimization of intracellular delivery of PNAs and small nucleic acids.
主要荣誉&奖项
Gilman Special Opportunity Award (2017-2018)
Excellence Postdoctoral Mentoring Award (2010)
McKnight Neuroscience Award (2009)
Welch Lectueship (2003)
CaP Cure Research Award (1996)
Damon Runyon Postdoctoral Fellowship (1990)
发表的主要文章
[7] Yue X, Schwartz J C, Younger S T, et al. Regulation of transcription by small RNAs complementary to sequences downstream from the 3’termini of genes[J]. Nature chemical biology, 2010, 6(8): 621.
[8] Hu J, Matsui M, Gagnon K T, et al. Allele-specific silencing of mutant huntingtin and ataxin-3 genes by targeting expanded CAG repeats in mRNAs[J]. Nature biotechnology, 2009, 27(5): 478.
[9] Corey D R. RNA learns from antisense[J]. Nature chemical biology, 2007, 3(1): 8.
[10] Janowski B A, Younger S T, Hardy D B, et al. Activating gene expression in mammalian cells with promoter-targeted duplex RNAs[J]. Nature chemical biology, 2007, 3(3): 166.
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