Oklahoma Medical Research Foundation，简称OMRF，成立于1946年，是一所独立的、非营利性的高水平生物医学研究机构。研究所主要致力于心血管疾病、癌症、以及自身免疫性疾病等重大疾病的基础和转化医学研究。OMRF拥有超过700项美国和国际专利，并以部分专利技术为基础成立了14个生物技术公司。OMRF研究实力强劲，拥有完善的科研平台和支撑体系，包括Clinical Genomics Center、Human Phenotyping Core、Gnotobiotic Mouse Core、Quantitative Analysis Core等，能够为前沿科学研究的开展提供充分的技术支持和保障。OMRF位于Oklahoma City，毗邻University of Oklahoma Health Sciences Center和多个研究所，如Harold Hamm Diabetes Center，Dean McGee Eye Institute等，从而形成了一个研究气氛浓郁、合作交流密切的学术共同体。Oklahoma City是State of Oklahoma的首府，是一个非常宜居的城市。在那里可以体会到州府城市的大都会生活，如精致的饮食、NBA著名球队雷霆队的精彩比赛等。
OMRF非常重视对于博士后的培养。除了一流的研究条件和完善的福利待遇，研究所还通过诸如为博士后提供Travel Awards等多项举措促进博士后的职业发展。因此，OMRF连续多年进入《The Scientist》杂志评选出的“Best Places to Work for Postdocs”名单。
- Cover letter: 请描述教育和研究经历、取得的研究成果和未来的研究兴趣；
- Curriculum vitae；
Postdoctoral Positions in Vascular Metabolism
The laboratory of Dr. Pengchun Yu in the Cardiovascular Biology Research Program at the Oklahoma Medical Research Foundation (OMRF) is seeking postdoctoral scientists to investigate the metabolic regulation of vascular formation and its implications in vascular diseases.
The laboratory focuses on the interface between cellular metabolism and vascular biology. Dr. Yu has recently demonstrated that MYC/hexokinase 2 pathway-driven glucose metabolism in endothelial cells controls blood and lymphatic vessel formation dependent on fibroblast growth factor receptor (FGFR) signaling (Yu et al., Nature, 2017). Research projects of the laboratory will be built upon this important finding to further study the crosstalk between metabolic programs and angiogenic signaling events and to understand the involvement of cellular metabolism in the pathogenesis of vascular diseases. Multidisciplinary strategies will be employed, ranging from novel genetically-modified mouse models to cutting-edge systems biology tools including metabolomics and single-cell transcriptome analysis.
OMRF is an independent, nonprofit biomedical research institute. The innovative basic and translational research at OMRF covers several critical areas such as cardiovascular disease, autoimmune disease, and cancer. OMRF has made The Scientist magazine’s annual list of the “Best Places to Work for Postdocs” for many years. The institute offers postdoctoral fellows an exceptional research and training environment with state-of-the-art facilities and outstanding core technology laboratories including imaging, next-generation sequencing, and clinical genomics. Moreover, postdoctoral scientists are encouraged to apply for OMRF Postdoc Travel Awards to support their attendance at meetings or workshops.
Applicants should have a recent Ph.D. (or expect to receive a doctoral degree soon), possess excellent experimental and communication skills, and demonstrate solid training in cell biology, biochemistry, developmental biology, or mouse genetics with scientific publications. Previous research experience in metabolism is a plus but is not required. In addition to competitive salaries and comprehensive benefits, the successful candidates will be provided with strong support for developing an independent research career after postdoctoral training.
Please send (1) a cover letter describing your previous training, research accomplishments, and future research interests, (2) your curriculum vitae, and (3) contact information of three references to Dr. Pengchun Yu at Pengchun-Yu@omrf.org.